- CGRP antibody:
CGRP = Calcitonin Gene-Related Peptide.
The cell bodies of the trigeminal ganglion are the main source of CGRP production.
During cluster headache attacks caused by administration of nitroglycerine, a visible increase in the level of CGRP in the blood plasma was measured.
When CGRP is administered to cluster headache patients, attacks are caused in episodic patients in the active phase and (slightly less) in chronic patients, but not in episodic patients in the remission phase.
The idea of making antibodies from CGRP came from these two facts.